Give clients insight into their genetic predisposition to health conditions
Through the iGenius DNA Dashboard, genetic information about the predisposition to common health conditions is made clearly visible.
For each condition, it is clearly shown whether the client has an increased or decreased genetic risk. The results include relevant gene variants, a scientific explanation and practical lifestyle advice. This information can be incorporated into treatment plans, lifestyle guidance or preventive care advice - making it possible to fully tailor care to the client's DNA.
Below you'll find a selection of relevant genes included in the analysis for each condition. The underlying pages provide additional information on the genetic background, risk mechanisms and lifestyle interventions.
Alzheimer's disease
ABCA7, APOE, BIN1, CD33, CLU, CR1, PICALM, TOMM40, TREM2
Stroke
ACE, APOE, F2, F5, HDAC9, NINJ2, PITX2, SH2B3, ZFHX3
Breast cancer
CASC8, CHEK2, EMBP1, ESR1, FGFR2, IGFBP5, MRPS30, RAD51B, SLC4A7, TERT, TNRC9
Osteoporosis
COL1A1, FOXL1, LRP5, MEF2C, TNFRSF11B, VDR, WNT4, WNT16
Colorectal cancer
APC, BMP2, BMP4, CCND2, CHEK2, COLCA2, CYP1A1, GREM1, MUTYH, MYC, NQO1, SMAD7
Type 2 diabetes
CDKAL1, CDKN2, FTO, GCK, GCKR, HHEX, IGF2BP2, KCNJ11, KCNQ1, PPARG, SLC30A8, TCF7L2
Ovarian cancer
NFKB1, RAD51, VDR, XRCC2
Glaucoma
ABCA1, AFAP1, ARHGEF12, ATXN2, CAV, CDKN2B-AS1, FOXC1, GAS7, SIX6, TMCO1, TXNRD3
Cardiovascular disease
ABO, ACE, ADAMTS7, APOA1, APOB, APOC3, APOE, CDKN2B-AS1, ICAM1, LDLR, LIPA, LPA, MRPS6, NOS3, PCSK9, PDGFD, PLPP3, WDR12
Liver cancer
EGF, ERCC2, KIF1B, MDM2, MIR196A2, PNPLA3
Lung cancer
BAT3-MSH5, CHRNA5, CYP2A6, DNAJB4, ERCC2, MPZL2, MTAP, RAD52, SECISBP2L, TERT, TP63
Stomach cancer
COX2, IL1B, IL10, MUC1, NQO1, PARP1, PRKAA1, PSCA, TLR4, TNF
Macular degeneration
ABCA4, ARMS2, C3, CFH, ERCC6, FBLN5
Parkinson's disease
GAK, GBA, GIGYF2, HIP1R, LRRK2, MAPT, MCCC1, PARK16, SNCA, STK39
Rheumatoid arthritis
AFF3, BLK, CCR6, CD40, CTLA4, HLA-DRB1, IL2RA, PTPN22, SPRED2, STAT4, TNFAIP3
Esophageal cancer
ADH1B, ALDH2, BARX1, CRTC1, CYP1A1, EGF, ERCC2, FOXP1, GDF7, NQO1, PLCE1
Insight into biochemical processes
In the iGenius DNA Dashboard, you as a healthcare professional receive personalised information for each client on the functioning of 7 key biochemical processes in the body.
The results are clearly organised by process. For each result you can click through for detailed DNA data and schematic overviews of the processes. The dashboard also includes personal points of attention and advisory considerations, based on the DNA analysis.
Methylation
- Folate cycle (incl. MTHFR, MTR)
- Methionine cycle (incl. MTRR, BHMT, PEMT)
- Transsulfuration pathway (incl. CBS, SUOX)
Detoxification
- Efficacy of detoxification enzymes and transport proteins
- Broken down into phase 0, phase 1, phase 2 and phase 3 detoxification
Oxidative stress
- Information on the enzymes involved (processing ROS)
- Genes involved: incl. SOD, CAT, GPX
Estrogens
- Information on enzymes involved in estrogen synthesis, metabolism and elimination
- Genes involved: incl. CYP17A1, CYP1B1, COMT, GSTs
Neurotransmitters
- Information on the processing and production of neurotransmitters such as dopamine, serotonin, melatonin, adrenaline and histamine
- Genes involved: incl. COMT, MAO, DAO, DRD4, BDNF
Vitamins and minerals
- Information on the processing and conversion of vitamins and minerals (incl. vitamin B6, B9, B12, D and magnesium)
Inflammation
- Information on cytokines, receptors, receptor antagonists and binding proteins involved in inflammatory mechanisms
- Cytokines involved: incl. IL1, IL6, TNF, IL10
Give clients insight into personal genetic traits
The iGenius DNA Dashboard provides insight into genetic variations linked to personal traits. These traits vary widely and affect nutrition, health and physical characteristics. Think of food intolerances and sensitivities (gluten, fructose, lactose), metabolic and blood clotting disorders (AATD, haemochromatosis) and physical traits (alopecia, muscle fibre type).
For each trait, it is clearly shown which genetic variants contribute to it. The results include a clear explanation and concrete, actionable guidance for healthcare professionals, so you can tailor nutritional advice, lifestyle guidance or treatment more precisely to your client's genetic profile.
Below you'll find a selection of the most relevant genetic variants included in the analysis for each trait. The underlying pages provide additional information on the genetic background and possible lifestyle interventions.
Alcohol sensitivity
ADH1B, ALDH2
Androgenetic alopecia (hair loss)
AR, EDA2R, FGF5, HDAC9, SLC14A2
Alpha-1 antitrypsin deficiency (AATD)
SERPINA1
Bitter taste perception
TAS2R38
Caffeine sensitivity
CYP1A2
Hereditary fructose intolerance (HFI)
ALDOB
Coeliac disease (gluten)
HLA-DQA1, HLA-DQB1
Norovirus resistance
FUT2
Lactose intolerance
LCT
Fast-twitch muscle fibres
ACTN3
Thrombophilia
F2, F5, SERPINC1, PROC, PROS1
SARS susceptibility (2003)
AHSG, MX1, OAS1, MBL2, CCL2
Haemochromatosis (iron overload)
HFE
Sensitivity to pain and stress
COMT
Wilson's disease (copper accumulation)
ATP7B
Give clients insight into genetic sensitivity to medication
More than 95% of people carry one or more genetic variants for which an adjusted dosing recommendation applies. The dashboard shows, per client, whether genetic variations are present that can affect the effectiveness of medication or the risk of side effects.
The iGenius DNA Dashboard provides insight into genetic variations that can influence the efficacy, dosing and safety of medications. Think of commonly used medicines such as painkillers, antidepressants, antipsychotics, blood thinners and cholesterol-lowering drugs. For each enzyme, transport protein or HLA type, the analysis shows genetic variations that affect the breakdown, activation, uptake or sensitivity to certain medications. This information helps you tailor medication choices more precisely to the client's DNA profile - with the goal of prescribing more safely, more personally and more effectively.
These insights are based on the KNMP/DPWG (Dutch Pharmacogenetics Working Group) guidelines and align with day-to-day prescribing practice and medication safety monitoring. For more extensive pharmacogenetic profiles, iGene Pharmaco is available: an additional solution for laboratories, pharmacists and pharmacy organisations. This includes the PGx Dose Support system, offering detailed PGx information, evidence-based medication choices and dosing recommendations per client.
Below is an overview of the key enzymes included in the analysis, along with their associated medications.